Mechanism and Research Progress of Mitochondrial Quality Control in Osteoarthritis
Keywords:
osteoarthritis, mitochondrial quality control, mitochondrial biogenesis, mitochondrial autophagy, mitochondrial dynamics
Abstract
Osteoarthritis (OA) is a chronic disease characterized by degenerative lesions of articular cartilage, which is characterized by cartilage degeneration, bone redundancy formation and synovial inflammation. Recent studies have found that mitochondrial dysfunction is closely related to the development of OA. Mitochondrial quality control (MQC) mechanisms, including mitochondrial biogenesis, mitochondrial dynamics and mitochondrial autophagy, are essential for maintaining mitochondrial function. Therefore, targeted regulation of mitochondrial quality control is a promising therapeutic strategy. This article reviews the mechanism of MQC and its relationship with OA, as well as the research progress of targeting and regulating MQC to prevent and treat OA, aiming to provide a theoretical basis for the pathogenesis and preventive strategies of OA.
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[17] Jin, J. Y., Wei, X. X., Zhi, X. L., et al. (2021). Drp1-dependent mitochondrial fission in cardiovascular disease. Acta Pharmacologica Sinica, 42(5), 655–664. https://doi.org/10.1038/s41401-020-00518-y
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[19] Hu, C., Huang, Y., & Li, L. (2017). Drp1-dependent mitochondrial fission plays critical roles in physiological and pathological progresses in mammals. International Journal of Molecular Sciences, 18(1), 144. https://doi.org/10.3390/ijms18010144
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[23] Ansari, M. Y., Novak, K., & Haqqi, T. M. (2022). ERK1/2-mediated activation of DRP1 regulates mitochondrial dynamics and apoptosis in chondrocytes. Osteoarthritis and Cartilage, 30(2), 315–328. https://doi.org/10.1016/j.joca.2021.11.003
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[25] Risbud, M., Madhu, V., Hernandez-Meadows, M., et al. (2024). The loss of OPA1 accelerates intervertebral disc degeneration and osteoarthritis in aged mice. https://doi.org/10.21203/rs.3.rs-3950044/v1
[26] Moqbel, S. A. A., Zeng, R., Ma, D., et al. (2022). The effect of mitochondrial fusion on chondrogenic differentiation of cartilage progenitor/stem cells via Notch2 signal pathway. Stem Cell Research & Therapy, 13(1), 127. https://doi.org/10.1186/s13287-022-02758-7
[27] Yao, X., Zhang, J., Jing, X., et al. (2019). Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission. Pharmacological Research, 139, 314–324. https://doi.org/10.1016/j.phrs.2018.09.026
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[30] Okatsu, K., Uno, M., Koyano, F., et al. (2013). A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment. Journal of Biological Chemistry, 288(51), 36372–36384. https://doi.org/10.1074/jbc.M113.509653
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