Modern Health Science

Is Ocular Counter-Roll Otolith-Ocular Reflex?

2025-03-12T10:44:53+08:00

Purpose

Ocular counter-roll has been thought to be an otolith-ocular reflex. However, there is a hypothesis that it is a semicircular canal (SCC) ocular reflex. This study aimed to validate whether ocular counter-roll can be explained by the SCC theory.

Methods

Experiment 1: Two springs with plastic balls (different turning radius) were fixed to a swivel chair and were rotated suddenly. Experiment 2: Subject was seated and the entire upper body was bent forward 60 degrees with the neck fixed. Experiment 3: Subject was seated, the head was twisted 45 degrees to the right and the entire upper body was bent forward 60 degrees with the neck fixed. Experiment 4 (roll rotation): Subject was asked to tilt his upper body 60 degrees to the left. Eye movements in the dark were observed and recorded using an infrared camera. In Experiments 2, 3 and 4, subjects were four healthy humans.

Results

Experiment 1: Immediately after the movement, the two balls moved tangentially. The ball on the outside spring moved more compared to the ball attached to the inside spring. Experiment 2: In all subjects, nystagmus was vertical. The direction was downward. Experiment 3: In all subjects, nystagmus was vertical/torsional. The direction was downward (torsional component was leftward). Experiment 4: In all subjects, nystagmus was torsional, and the direction was leftward.

Conclusion

Since the role of SCCs is to sense angular acceleration in all directions of 360 degrees in a coordinated manner, bilateral vertical SCCs are stimulated in roll rotation. Therefore, SCC theory can explain the generation of ocular counter-roll. We proposed the “difference of inertial forces” theory to explain the mechanism of vestibulo-ocular reflex.

Integrating Acupuncture and Mindfulness for Depression: Clinical Evidence, Mechanistic Understanding, and a Case Study in Adolescent Treatment

2025-04-12T13:12:04+08:00

Depression represents a significant global health challenge, with conventional treatments limited by efficacy gaps, side effects, and accessibility barriers. This paper investigates the integrative application of acupuncture and mindfulness as a novel, non-pharmacological approach to depression management, leveraging their complementary neurobiological and psychological mechanisms. We synthesize contemporary clinical and neuroscientific evidence supporting each modality individually, propose a theoretical framework for their combined application, and present an illustrative case study of a 15-year-old female with moderate depression (baseline PHQ-9: 12; BDI-II: 25). The patient underwent a 12-week program combining electroacupuncture and mindfulness-based interventions, resulting in significant symptom remission (final PHQ-9: 3; BDI-II: 6), alongside improvements in mood, energy, and daily functioning. The treatment integrated acupuncture's modulation of neurotransmitter systems and stress pathways with mindfulness's enhancement of emotional regulation and neuroplasticity, demonstrating potential synergistic effects. This case provides preliminary evidence of efficacy, particularly for adolescents seeking alternatives to pharmacotherapy. These findings underscore the need for rigorous controlled trials to validate this integrative strategy and establish its role in contemporary depression management, offering a translational framework for future research and clinical practice.

Home-based vs. Nursing Home Care: A Comparative Study on the Quality of Life of the Elderly in Nantong

2025-04-23T01:10:45+08:00

Background: China’s aging population underscores urgent challenges in elderly care. In this study, quality of life (QoL) and nutritional status were compared between elderly populations in home-based and nursing home care to inform care strategies. Methods: A stratified random sample of elderly residents in the Chongchuan, Nantong, was assessed using online and offline questionnaires. The data were analyzed using SPSS 27.0. Results: Nursing home residents exhibited significantly lower QoL across all dimensions than home-based elderly. Female elderly exhibited significantly higher mean scores across all QoL dimensions than males. Individuals aged 60–69 years scored higher across all dimensions than the other age groups. Academic qualifications significantly influenced two dimensions, with higher academic qualifications associated with better outcomes. Pre-retirement occupation showed significant effects on four dimensions, although no inter-occupational differences were observed. Income significantly impacted one dimension, with higher income correlating with a better QoL. Significant effects of marital status were observed. Frequency of contact with children only influenced one dimension, with no differences across contact levels. Chronic diseases significantly affected all dimensions. Home-based elderly individuals had higher Mini Nutritional Assessment Short-Form (MNA-SF) scores than nursing home residents. MNA-SF scores showed significant positive correlations with all QoL dimensions. Conclusions: The higher QoL and nutritional status of home-based elderly individuals compared to nursing home residents was attributed to stronger family support, greater autonomy, and familiar environments. Care setting selection should consider health status and family support. Interventions targeting mental health, social interactions, and nutrition are essential for improving QoL in nursing homes.

A Review of the Effects of Multimodal Interventions in the Rehabilitation Department of a Class III Grade A Hospital on the Enhancement of Social Skills in Autistic Children

2025-04-29T12:58:32+08:00

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that severely affects the social interaction and communication abilities of children. Social skills deficits are one of the core symptoms of ASD, which have a significant impact on the quality of life and future development of autistic children. Multimodal interventions in the rehabilitation department of Class III Grade A hospitals have emerged as a promising approach to address these social skill deficits. This review article comprehensively examines the existing literature on the effects of multimodal interventions on the social skills of autistic children. It first introduces the background and significance of studying social skills in autistic children. Then, it delves into the concept and components of multimodal interventions, including behavioral therapy, speech therapy, occupational therapy, and other related modalities. The review also analyzes the mechanisms through which multimodal interventions enhance social skills, such as improving communication, promoting emotional recognition, and facilitating social interaction. Furthermore, it evaluates the effectiveness of these interventions based on various research findings. Finally, the article concludes by summarizing the current state of research, pointing out the limitations of existing studies, and suggesting directions for future research. Through this review, it is hoped to provide a comprehensive understanding of the role of multimodal interventions in improving the social skills of autistic children and contribute to the development of more effective rehabilitation strategies.

Synthesis and Crystal Structure as well as Cytotoxicity Analysis of Dichloro-Terpyridine-Copper Complex

2025-05-30T23:01:18+08:00

Malignant tumors, recognized as one of the most threatening diseases of the 20th century, continue to exhibit a rising incidence trend in the 21st century. Against this backdrop, metal complexes have attracted considerable attention due to their unique antitumor activities. In this study, we unexpectedly obtained a copper-based complex coordinated with 2,2':6',2''-Terpyridine and chloride anion ligands, and characterized its crystal structure using X-ray single-crystal diffraction technique. The cytotoxic effects of this metal complex against various tumor cell lines were evaluated through MTT assays, and the findings provide significant theoretical and practical foundations for developing novel anticancer drugs.

A Case Report of Chronic Kidney Disease Stage 5 Complicated with Uremic Tumor Calcinosis

2025-05-09T12:54:09+08:00

Uremic tumor calcinosis (UTC) represents an extremely rare complication associated with chronic kidney disease (CKD), prominently characterized by the occurrence of ectopic calcification. The incidence of UTC among uremic peritoneal dialysis patients has been estimated to be approximately 1.60%. This specific case report aims to illuminate the intricate diagnostic and therapeutic challenges encountered in a dialysis patient. A 74-year-old male, diagnosed with stage 5 CKD and undergoing peritoneal dialysis, presented with a considerable 12x5 cm soft tissue mass on his back. Through a comprehensive array of imaging studies and histopathological examinations, the mass was subsequently identified as UTC. The diagnostic process revealed elevated levels of Parathyroid hormone (PTH) at 445.100 pg/ml and phosphorus at 2.77mg/dl. The diagnosis was ultimately confirmed via surgical resection. The patient's condition was managed and stabilized through the administration of phosphate binders and calcitriol. This case significantly underlines the critical necessity of vigilant and continuous monitoring of calcium-phosphorus metabolism in patients with CKD. Furthermore, it highlights UTC as an important differential diagnosis consideration when confronted with soft tissue masses.

Study on the Mechanism of miR-520d-5p and LMO4 in Regulating Thyroid Cancer Progression

2025-05-16T21:51:29+08:00

The pathogenesis of thyroid cancer is closely related to environmental factors. Gene mutation and molecular biological changes of thyroid tissue caused by environmental changes are one of the important factors inducing thyroid cancer. Although the molecular mechanism of thyroid cancer is still not fully elucidated, with the development of molecular biology technology, more and more thyroid cancer-specific genetic changes and molecular markers have been excavated. This article systematically summarizes the current research progress of miR-520d-5p and LMO4 in thyroid cancer, and discusses how they participate in the regulation of the biological behavior of tumor cells and potential molecular signaling pathways, so as to provide new theoretical basis and ideas for the precise diagnosis and treatment of thyroid cancer.

Research Progress on Acupuncture in the Treatment of Olfactory Disorders after Upper Respiratory Tract Infection

2025-05-17T09:18:52+08:00

Olfactory disorder after upper respiratory tract infection is a common clinical condition, which is mainly manifested as loss or loss of sense of smell, which not only affects people's quality of life, but also may bring potential safety hazards due to the inability to accurately identify harmful gases, such as natural gas leakage and fire warning. In recent years, acupuncture, as a characteristic therapy of traditional Chinese medicine, has shown unique advantages in the treatment of this disease because of its safety, effectiveness, and few side effects. This article reviews the research progress of acupuncture in the treatment of olfactory disorders after upper respiratory tract infection. It discusses the understanding of the disease by traditional Chinese medicine and the reports of external treatment methods of traditional Chinese medicine to treat the disease, to promote the application of acupuncture in the treatment of olfactory disorders.