Modern Health Science

Cross-Cultural Dietary Integration and Health Promotion: The Application and Potential of Chinese-Western Fusion Cuisine in Modern Health Science

Donghui Li — 2024-12-09

The fusion of Chinese and Western culinary traditions has evolved into a unique gastronomic phenomenon that bridges cultural boundaries while promoting health. This paper explores the intersection of Chinese-Western fusion cuisine and modern health science, analyzing its historical development, global influence, and contributions to healthy eating. By merging diverse ingredients, techniques, and health-focused innovations, fusion cuisine achieves both gastronomic satisfaction and nutritional balance. Utilizing systematic sample analysis, nutritional assessments, and case studies, this research highlights the potential of fusion cuisine in preventing chronic diseases, enhancing immunity, and fostering cultural appreciation. The findings underscore the pivotal role of fusion cuisine in advancing global dietary diversity and promoting sustainable, health-conscious food practices. Future directions are proposed for research and global promotion to unlock the full potential of this culinary innovation.

Comparison of in Vitro Proliferation and Antioxidant Activity Between Ginseng-Derived Exosome-Like Nanoparticles and Ginseng Original Liquid

Bing Jin — 2024-12-12

To compare the proliferation and antioxidant activity of Ginseng-derived exosome-like nanoparticles (GELNs) and Ginseng extracts (GEXs) in vitro. GEXs were prepared from natural plant ginseng, and GELNs were extracted by ultracentrifugation combined with sucrose density gradient centrifugation. The CCK-8 method was used to compare the effects of GELNs and GEXs on the proliferation of skin cells. The scratch test was used to compare the effects of GELNs and GEXs on the migration ability of skin cells, and then to verify the ability of GELNs and GEXs to promote proliferation, the antioxidant activity of GELNs and GEXs was compared by OH + DPPH + ABTS + FRAP method. The results showed that although GELNs and GEXs could promote the proliferation of human keratinocytes cells (HaCaT) at a certain concentration, GELNs not only showed better ability to promote the proliferation of skin cells, but also showed good biosafety. In addition, under the same protein concentration, GELNs showed stronger ability to scavenge OH, DPPH, ABTS free radicals and reduce iron ions than GEXs, that is, GELNs had relatively stronger antioxidant activity. The GELNs obtained by purification technology potentially improved the bioavailability and biosafety of ginseng, in order to provide a theoretical basis for its in-depth study as a natural antioxidant.

Principles of Standardized Diagnosis and Treatment of Immune Checkpoint Inhibitors (ICIs) and Analysis of Legal Liability for Treatment-Related Tumor Hyperprogression (HPD) Under Chinese Law

Wu Chuyan — 2024-12-15

Immunotherapy, led by immune checkpoint inhibitors, has reshaped the landscape of tumor treatment, achieving long-acting drug responses in some patients with advanced malignancies, but not all patients can benefit from immunotherapy. In addition to primary drug-resistant patients, we cannot ignore hyperprogressive patients whose disease is accelerated instead after the use of immune checkpoint inhibitors, which are rare but often have a very poor prognosis and are prone to disputes. The mechanism of hyperprogression is still unknown, but not unknown, and some genetic mutations and biomarkers have been shown to be associated with a higher risk of hyperprogression. Clinicians should stratify patients with reference to markers and risk mutations to screen effective patients and inform them of the corresponding risks of immune checkpoint inhibitor therapy to ensure that patients make a fully informed choice of immunotherapy. Comply with evidence-based medical guidelines, standardize the use of medication, and timely monitor and intervene in related adverse events and hyperprogression. Under Chinese law, violation of the principles of diagnosis and treatment is subject to liability, except for those caused by the patient himself, such as backline treatment and sympathetic drug administration.

Exploration of the Antitumor Mechanism of Fruquintinib in Colorectal Cancer via Autophagy Regulation

Peng Yan — 2024-12-25

Colorectal cancer (CRC) ranks as the second leading cause of cancer-related mortality worldwide, with treatment challenges largely attributed to late-stage diagnoses, frequent recurrences, and resistance to therapy. In recent years, Fruquintinib, a selective vascular endothelial growth factor receptor (VEGFR) inhibitor, has shown notable effectiveness in advanced CRC by targeting angiogenesis. However, CRC cells often activate autophagy in response to hypoxia and nutrient deprivation caused by anti-angiogenic therapy, which diminishes the therapeutic efficacy of Fruquintinib. Autophagy plays a dual role in CRC by suppressing tumorigenesis through the removal of damaged organelles, while facilitating tumor progression and therapeutic resistance through metabolic adaptation in advanced stages. This complexity underscores the therapeutic promise of strategies targeting autophagy. Current studies reveal that Fruquintinib induces autophagy by inhibiting VEGFR signaling, activating AMPK, and suppressing mTOR, while interacting synergistically with other cell death mechanisms such as apoptosis, ferroptosis, and pyroptosis to enhance its antitumor activity. However, excessive autophagy activation may enable tumor cell survival and promote resistance, highlighting the necessity of precise modulation of autophagy in combination therapies. Moreover, preclinical studies indicate that combining Fruquintinib with autophagy modulators significantly enhances its antitumor effects and delays resistance emergence. This review offers a systematic analysis of Fruquintinib's antitumor mechanisms via autophagy modulation and its potential clinical implications. Based on the reviewed evidence, we propose strategies to optimize Fruquintinib-based combination therapies, including the use of autophagy-related biomarkers, autophagy modulators, and precision medicine approaches tailored to tumor genomic profiles, aiming to enhance treatment outcomes for CRC patients.

A Comparative Analysis of the Clinical Outcomes of Two Surgical Techniques for the Treatment of Senile Lower Eyelid Entropion with Trichiasis

Rui Huang — 2024-12-26

This study investigates the clinical efficacy of different surgical methods for treating senile entropion with trichiasis of the lower eyelid and their effectiveness in alleviating symptoms.A total of 54 cases of elderly patients with senile entropion and trichiasis of the lower eyelid were included as study subjects. They were divided into a control group (30 cases, 46 eyes) treated with eyelid skin and orbicularis oculi muscle excision, and an observation group (24 cases, 40 eyes) treated with orbicularis oculi muscle shortening combined with marginal inversion suture.The clinical efficacy of the two groups was compared, and improvements in ocular symptoms were assessed using specialized scales.Results: Both groups demonstrated high surgical efficacy with no statistically significant difference (P>0.05). The observation group exhibited higher tear film breakup time (BUT) and tear meniscus height (TMH), and lower corneal fluorescein staining (CFS) and ocular surface disease index (OSDI) scores compared to the control group. These differences were statistically significant (P<0.05).The incidence of postoperative complications was low in both groups, with no statistically significant differences (P > 0.05).For elderly patients with lower eyelid entropion, the procedure of orbicularis oculi muscle shortening combined with marginal inversion suture can achieve definitive clinical efficacy and significantly alleviate ocular discomfort.

Research Status of Traditional Chinese Medicine in the Treatment of Gastric Precancerous Lesions

Yuxin Jing — 2024-12-30

Gastric cancer is an extremely common malignant tumour in China, with high morbidity and mortality rates, posing a serious threat to the life and health of the people. Pre-cancerous gastric lesions are considered to be an important stage in the development of gastric cancer, so timely monitoring of pre-cancerous gastric lesions and effective treatment are the key links in the prevention and control of gastric cancer. Traditional Chinese medicine has been widely used in the treatment of gastric precancerous lesions and has shown its unique advantages. This article systematically describes the etiology and mechanism of this disease and the current status of clinical treatment research, with the aim of providing valuable references for the formulation of clinical treatment plans and the development of related medicines.