https://j.ideasspread.org/index.php/mhs <p>Modern Health Science (MHS) is an international, double-blind peer-reviewed, open-access journal, published by IDEAS SPREAD INC. It publishes original research, applied, and educational articles in all areas of health science. It provides an academic platform for professionals and researchers to contribute innovative work in the field.<br>Authors are encouraged to submit complete, unpublished, original works that are not under review in any other journals.<br>The journal is published in both print and online versions. The online version is free access and download.</p> IDEAS SPREAD INC en-US Modern Health Science 2576-7291 <p>Copyright for this article is retained by the author(s), with first publication rights granted to the journal.<br>This is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).</p> https://j.ideasspread.org/index.php/mhs/article/view/1578 <p class="text">Objective:</p> <p class="text">The utricle is commonly understood to detect gravity and horizontal linear acceleration. We hypothesized that it may also respond to vertical linear acceleration, horizontal angular acceleration, and centrifugal force.</p> <p class="text">Methods:</p> <p class="text">We performed six physical analogy experiments using deformable media, spring-mounted masses, and human squatting tasks (five healthy humans). Observations included deformation patterns and eye movement recordings.</p> <p class="text">Results:</p> <p class="text">(1) Submerged lead deformed the pudding, modeling gravitational deformation. (2–3) Spring-mounted masses deflected opposite to the direction of acceleration. (4) Human vertical motion did not elicit nystagmus. (5) Sudden rotation caused tangential deflection. (6) Constant-speed circular motion led to outward (centrifugal) deflection.</p> <p class="text">Conclusion:</p> <p class="text">The utricle can detect four distinct forces—gravity, horizontal and vertical linear acceleration, tangential angular acceleration, and centrifugal force—which suggests broader roles in postural control. Although utricular hair cells are continuously stimulated by Earth’s gravity, no nystagmus is observed under static conditions. Thus, static utricular activation alone does not elicit nystagmus. However, further studies are needed to quantify these effects and determine their physiological significance.</p> Hiroaki Ichijo Hisako Ichijo ##submission.copyrightStatement## http://creativecommons.org/licenses/by/4.0 2025-05-31 2025-05-31 8 3 p1 p1 10.30560/mhs.v8n3p1 https://j.ideasspread.org/index.php/mhs/article/view/944 <p class="Abstract" style="margin: 12.0pt 0cm 12.0pt 0cm;"><span lang="EN-GB">Osteoarthritis (OA) is a chronic disease characterized by degenerative lesions of articular cartilage, which is characterized by cartilage degeneration, bone redundancy formation and synovial inflammation. Recent studies have found that mitochondrial dysfunction is closely related to the development of OA. Mitochondrial quality control (MQC) mechanisms, including mitochondrial biogenesis, mitochondrial dynamics and mitochondrial autophagy, are essential for maintaining mitochondrial function. Therefore, targeted regulation of mitochondrial quality control is a promising therapeutic strategy. <span style="color: black;">This article reviews the mechanism of MQC and its relationship with OA, as well as the research progress of targeting and regulating MQC to prevent and treat OA, aiming to provide a theoretical basis for the pathogenesis and preventive strategies of OA.</span></span></p> Yan Li Jiushe Kou ##submission.copyrightStatement## http://creativecommons.org/licenses/by/4.0 2025-07-22 2025-07-22 8 3 p7 p7 10.30560/mhs.v8n3p7 https://j.ideasspread.org/index.php/mhs/article/view/1674 <p>The circadian rhythm and sleep quality of seafarers are critical for their health and maritime safety; however, both are highly susceptible to disruption by environmental factors specific to different navigational regions. In particular, trans-meridian (east-west) voyages involving rapid time-zone crossings, and high-latitude (north-south) voyages encountering polar day/night phenomena, can severely disrupt the human circadian system. This study aims to investigate the potential modulatory effects of Tai Chi, as a non-pharmacological and easily implementable mind-body intervention, on the circadian rhythms and sleep quality of seafarers under different navigational conditions and to explore its differential mechanisms. This paper first systematically analyzes the core challenges to circadian rhythms posed by two typical navigational regions: the former leading to phase desynchronization between the internal clock and the external environment, and the latter causing a deficiency or disturbance of the primary zeitgeber (light). Subsequently, the paper reviews the scientific evidence for Tai Chi’s role in regulating the autonomic nervous system, optimizing neuroendocrine rhythms, and improving sleep architecture. Based on this, a core theoretical model is proposed, positing that Tai Chi may act as a potent “non-photic zeitgeber”. Through regular, daily practice at a fixed time, it can provide a stable and predictable synchronizing signal to the seafarer’s internal biological clock. We further hypothesize that Tai Chi’s mechanism of action is context-dependent: during trans-meridian voyages, it primarily serves as a rhythmic anchor to accelerate phase re-entrainment and combat jet lag; during high-latitude voyages, it functions to substitute and enhance a weak or absent light signal, helping to maintain the stability of endogenous rhythms. To validate this model, a 2x2 factorial designed randomized controlled trial is proposed to prospectively compare changes in circadian rhythms (measured by actigraphy and salivary hormones) and subjective sleep quality between a Tai Chi intervention group and a control group across the two different navigational regions. This research not only aims to provide an innovative and scientific intervention for the sleep and rhythm problems faced by seafarers in extreme environments but also seeks to deepen the understanding of mind-body exercise as a form of behavioral chronotherapy, thereby opening new avenues for safeguarding the health and safety of special occupational populations.</p> Mengjiao Guo Haonan Zheng ##submission.copyrightStatement## http://creativecommons.org/licenses/by/4.0 2025-07-22 2025-07-22 8 3 p16 p16 10.30560/mhs.v8n3p16