Formulation and Quality Optimization of Effervescent Tablet of Glipizide: An Approach to Comfort Anti-Diabetic Medication

  • Aklima Aklima Department of Pharmacy, Noakhali Science and Technology University, Bangladesh
  • Prodip Kumar Baral Department of Pharmacy, Noakhali Science and Technology University, Bangladesh
  • Mohammad Tohidul Amin Department of Pharmacy, Noakhali Science and Technology University, Bangladesh
  • Tariqul Islam Emon Department of Pharmacy, Noakhali Science and Technology University, Bangladesh
  • Mohammad Salim Hossain Department of Pharmacy, Noakhali Science and Technology University, Bangladesh
Keywords: anti-diabetic, dissolution, drug solubility, flow property, granulation


The present study is targeted to formulate and prepare effervescent tablets of Glipizide to provide more elegancy, comfortability, and improved pharmacokinetics in diabetic treatment than the conventional dosage. Three formulations (F1, F2, and F3) of the effervescent tablet of Glipizide (5mg) were formulated with different amounts and ratios of excipients. By wet granulation technique, 60 tablets for every formulation were prepared with a weight of 700mg per tablet. Then, the features of both granules and tablets were evaluated by published methods. The angle of repose, Hausner ratio, Carr's index, Loss on drying (LOD), and Moisture Content (MC) used to measure granules property successfully proved right follow ability and compressibility. In contrast, physical and drug content related investigation failed to determine the perfectness of all three formulations. Friability on the formulations was around 0.70%, indicating the expected USP limit of friability (0.5 to 1%). The mean disintegration time of the formulations was from 95s to 105s. The tablet potency assay found 95.20% for F1, 88.80% for F2, and 97.40% for F3. The dissolution pattern of the drug followed a linear relationship with time. After one and a half hours, the highest amount of 59.20% cumulative dissolution was determined for F3 that revealed its strategic improvement of the drug solubility. As Glipizide is a poorly water-soluble drug, the effervescent tablet might mitigate disintegration and dissolution-related limitations and, consequently, enhance the drug's bioavailability.


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The cumulative percentage of drug dissolution from the tablets of the three formulations with different time intervals