Progress in the Treatment of Depression Combined with Insomnia with Different Amounts of Acupuncture Stimulation

  • Lixiu Nan Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, China
  • Shan Qin Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, China
Keywords: depression, insomnia, electroacupuncture, electroacupuncture frequency, electroacupuncture waveforms

Abstract

Depression and insomnia are common categories of physical and mental medicine, which are causative of each other and often occur as co-morbidities, causing a huge health and economic burden. Acupuncture treatment in insomnia co-morbidity mild-moderate depression shows better clinical efficacy, with multi-target, multi-pathway, multi-dimensional and other characteristics. However, the clinical efficacy and effect mechanism of acupuncture parameters have not been clearly determined, therefore, this paper systematically describes the possible mechanism of different acupuncture stimulation volume, including manipulation of the needle, electro-acupuncture waveform, electro-acupuncture frequency, acupuncture site, and other variables, and proposes that future research should focus on exploring the effect mechanism of different acupuncture stimulation volume in the treatment of the disease, with a view to providing theoretical basis and research ideas for the treatment of insomnia depression co-morbidities by acupuncture.

References

[1] Baglioni, C., Battagliese, G., Feige, B., et al. (2011). Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. Journal of Affective Disorders, 135(1-3), 10-19. https://doi.org/10.1016/j.jad.2011.01.011
[2] Cai, R. L., Shen, G. M., Wang, H., & Guan, Y. Y. (2018). Brain functional connectivity network studies of acupuncture: a systematic review on resting-state fMRI. Journal of Integrative Medicine, 16(1), 26-33. https://doi.org/10.1016/j.joim.2017.12.002
[3] Cao, Y., Xu, A., Xing, L., et al. (2009). Innovative principles and characteristics of acupuncture manipulation electroacupuncture instrument[C]//Shanghai University of TCM, The Acupuncture-Moxibustion Instruments Committee of China Acupuncture and Moxibustion Society. The Acupuncture-Moxibustion Instruments Committee of China Acupuncture-Moxibustion Society.) The Acupuncture-Moxibustion Instruments Committee of China Acupuncture-Moxibustion Society. Suzhou Medical Supplies Factory Co. Ltd; Nanwan University of Traditional Chinese Medicine; 2009:11.
[4] Cheng, W., Rolls, E. T., Ruan, H., & Feng, J. (2018). Functional Connectivities in the Brain That Mediate the Association Between Depressive Problems and Sleep Quality. JAMA Psychiatry, 75(10), 1052-1061. https://doi.org/10.1001/jamapsychiatry.2018.1941
[5] Cheng, W., Quan, S., Li, X., et al. (2011). Clinical study on strengthening Yang's stimulation of Baihui point for treating depressive insomnia[J]. Journal of Chinese Traditional Medicine, 29(12), 2608-2609. https://doi.org/10.13193/j.archtcm.2011.12.10.chengwp.019
[6] Chung, K. F., Yeung, W. F., Zhang, S. P., et al. (2016). Acupuncture for persistent insomnia associated with major depressive disorder: a randomized controlled trial. Hong Kong Medical Journal, 22 Suppl 2, S9-S14.
[7] Difrancesco, S., Lamers, F., Riese, H., et al. (2019). Sleep, circadian rhythm, and physical activity patterns in depressive and anxiety disorders: a 2-week ambulatory assessment study. Depression and Anxiety, 36(10), 975-986. https://doi.org/10.1002/da.22949
[8] Dong, B., Chen, Z., Yin, X., et al. (2017). The Efficacy of Acupuncture for Treating Depression-Related Insomnia Compared with a Control Group: a Systematic Review and Meta-Analysis. BioMed Research International, 2017, 9614810. https://doi.org/10.1155/2017/9614810
[9] Expert consensus on the diagnosis and treatment of insomnia with depression and anxiety in Chinese adults[J]. (2020). Chinese Journal of Neurology, 53(08), 564-574.
[10] Hertenstein, E., Feige, B., Gmeiner, T., et al. (2019). Insomnia as a predictor of mental disorders: a systematic review and meta-analysis. Sleep Medicine Reviews, 43, 96-105. https://doi.org/10.1016/j.smrv.2018.10.006
[11] Jiang, J., Zhao, B., & Zhao, H. (2015). Effects of different waveforms of electroacupuncture on monoamine neurotransmitter content in the brain of PCPA-induced insomnia rats[J]. Chinese Medicine Herald, 21(21), 34-36. https://doi.org/10.13862/j.cnki.cn43-1446/r.2015.21.012
[12] Johnson, E. O., Roth, T., & Breslau, N. (2006). The association of insomnia with anxiety disorders and depression: exploration of the direction of risk. Journal of Psychiatric Research, 40(8), 700-708. https://doi.org/10.1016/j.jpsychires.2006.07.008
[13] Li, H., Gao, Q., & Li, Y. (2023). Observations on the efficacy of acupuncture on the Duchen point for the treatment of insomnia and the effects on patients' serum neurotransmitter levels[J]. Shanghai Journal of Acupuncture and Moxibustion, 42(10), 1030-1035. https://doi.org/10.13460/j.issn.1005-0957.2023.10.1030
[14] Li, Z. (2003). Experimental Acupuncture [M]. China Traditional Chinese Medicine Press.
[15] Liu, P. (2014). Study on the effects of electroacupuncture on anxiety and depression and sympathetic- adrenomedullary system in insomniac rats[D]. Chengdu University of Traditional Chinese Medicine.
[16] Liu, Q., Deng, L., Wang, F., et al. (2019). Clinical study of high frequency electroacupuncture combined with "small brain-opening" acupuncture method for the treatment of insomnia[J]. Journal of Zhejiang University of Traditional Chinese Medicine, 43(11), 1284-1287. https://doi.org/10.16466/j.issn1005-5509.2019.11.020
[17] Lv, Z., & Guo, Y. (2016). Rethinking Chinese medicine clinic proposed "skin is the third brain of human"[J]. Jiangxi Traditional Chinese Medicine, 47(07), 11-13+19.
[18] Riemann, D., Krone, L. B., Wulff, K., & Nissen, C. (2020). Sleep, insomnia, and depression. Neuropsychopharmacology, 45(1), 74-89. https://doi.org/10.1038/s41386-019-0411-y
[19] Tian, H., & Zhao, J. (2022). A randomized controlled study of the effects of strong and weak stimulus volume acupuncture on primary insomnia accompanied by depression and anxiety and quality of life in liver depression and fire type [J]. Chinese Journal of Traditional Chinese Medicine, 37(02), 1193-1197.
[20] Wang, S., Gao, J., Wu, B., et al. (2024). Interaction of depression and insomnia under acupuncture treatment: a secondary analysis of a randomized controlled trial [J]. Chinese Acupuncture and Moxibustion, 44(06), 618-624. https://doi.org/10.13703/j.0255-2930.20230822-k0001
[21] Wang, T., Su, S., Zhang, X., et al. (2023). Overview of the research on the mechanism of acupuncture in treating depression co-morbid insomnia[J]. Journal of Hainan Medical College, 29(15), 1182-1186. https://doi.org/10.13210/j.cnki.jhmu.20210823.005
[22] Wang, Y., Jiang, Z., Zhang, Y., et al. (2024). Progress and revelation of the research on the relationship between needle retention time and therapeutic efficacy[J]. Chinese Journal of Traditional Chinese Medicine, 39(08), 4229-4234.
[23] Wang, Y., Yu, Y., Wang, X., et al. (2024). A review of clinical studies on the treatment of insomnia by electroacupuncture in the past ten years[J]. World Chinese Medicine, 19(05), 645-651.
[24] Wen, S., Wang, J., Wu, J., et al. (2020). Mechanism analysis of the treatment of insomnia by acupuncture from the dui ren two channels[J]. Liaoning Journal of Chinese Medicine, 47(10), 167-169. https://doi.org/10.13192/j.issn.1000-1719.2020.10.051
[25] Xie, C., Huang, Q., Yang, G., et al. (2024). Bibliometric analysis based on the progress of appropriate diseases and clinical application of intradermal needle therapy[J]. Shanghai Journal of Acupuncture and Moxibustion, 43(05), 576-582. https://doi.org/10.13460/j.issn.1005-0957.2024.05.0576
[26] Yan, L., Li, Z., Zhang, Y., et al. (2023). Liver-sparing and Shen-tuning method of acupuncture combined with western medicine for the treatment of depression and insomnia co-morbidities caused by the isolation experience of the new crown epidemic : a multicenter randomized controlled trial[J]. Chinese Acupuncture and Moxibustion, 43(03), 255-260. https://doi.org/10.13703/j.0255-2930.20221030-k0004
[27] Yan, L., Zhou, P., Lai, M., et al. (2023). Acupuncture combined with low-frequency rTMS for the treatment of co-morbid insomnia in mild-to-moderate depressive disorders: a randomized controlled trial[J]. Chinese Acupuncture, 43(04), 374-378+400. https://doi.org/10.13703/j.0255-2930.20220730-k0001
[28] Yang, C., Chen, Y., Yang, Y., et al. (2021). Analysis of clinical selection pattern of acupuncture points for treating depressive insomnia[J]. Chinese Medicine Bulletin, 20(02), 42-46. https://doi.org/10.14046/j.cnki.zyytb2002.2021.02.013
[29] Yin, X., Li, W., Liang, T., et al. (2022). Effect of Electroacupuncture on Insomnia in Patients With Depression: a Randomized Clinical Trial. JAMA Network Open, 5(7), e2220563. Published 2022 Jul 1. https://doi.org/10.1001/jamanetworkopen.2022.20563
[30] Yu, L., Zhang, R., Tan, D., et al. (2022). Observation on the clinical efficacy of dredging and balancing acupuncture method for the treatment of chronic insomnia with anxiety and depression[J]. Chinese Medicine Information, 39(08), 55-59. https://doi.org/10.19656/j.cnki.1002-2406.20220809
[31] Zhang, P., Qu, X., & Liu, Z. (2019). Exploring the causes of fatigue phenomenon in meridians and acupoints[J]. Chinese Journal of Traditional Chinese Medicine, 34(02), 513-515.
[32] Zhao, F. Y., Kennedy, G. A., Spencer, S. J., et al. (2022). The Role of Acupuncture in the Management of Insomnia as a Major or Residual Symptom Among Patients With Active or Previous Depression: a Systematic Review and Meta-Analysis. Frontiers in Psychiatry, 13, 863134. Published 2022 Apr 15. https://doi.org/10.3389/fpsyt.2022.863134
[33] Zhao, Y., Wang, Y., Zhang, J., et al. (2022). Effects of auricular stimulation of transvagus nerve on polysomnographic features in patients with insomnia with depression[J]. Chinese Journal of Traditional Chinese Medicine, 37(10), 6168-6172.
[34] Zhang, Y., Wang, B., & Yang, J. (2024). Progress and revelation of the research on the relationship between needle retention time and therapeutic efficacy[J]. Chinese Journal of Traditional Chinese Medicine, 39(08), 4229-4234.
Published
2025-03-18
Section
Articles